A sulfur-containing nucleoside triphosphate derivative
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2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′,3′-dideoxy-guanosine, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Synonyms
  • ddGTP-α-S
  • α-S-ddGTP
Molecular Formula
C10H12N5O11P3S • 4Na
Formula Weight
595.2
Purity
≥95% (a mixture of Rp and Sp isomers)
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[O-]P(OP(OC[C@@H]1CC[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1)([S-])=O)(OP([O-])([O-])=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H16N5O11P3S.4Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(24-6)3-23-29(22,30)26-28(20,21)25-27(17,18)19;;;;/h4-6H,1-3H2,(H,20,21)(H,22,30)(H2,17,18,19)(H3,11,13,14,16);;;;/q;4*+1/p-4/t5-,6+,29?;;;;/m0..../s1
InChi Key
AFDVXAVZPVZVKF-UULGPNALSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.5 mg

    $366

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    Product Description

    2',3'-Dideoxyguanosine-5'-O-(1-thiotriphosphate) (ddGTP-α-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (α-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5'-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles.1 ddGTP-α-S has been used for chain extension using a mutated polymerase selective for dideoxynucleotides and chain termination in allele-specific PCR assays.2,1 ddGTP-α-S is a mixture of Rp and Sp isomers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tost, J., Schatz, P.F., Schuster, M., et al. Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry. Nucleic Acids Res. 31(9), e50 (2003).

    2. Sauer, S., and Gut, I.G. Extension of the GOOD assay for genotyping single nucleotide polymorphisms by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun. Mass Spectrom. 17(12), 1265-1272 (2003).