A sulfur-containing nucleoside triphosphate
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2',3'-Dideoxythymidine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3′-deoxy-thymidine, 5′→P′′-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Synonyms
  • ddTTP-α-S
  • ddtTTP
Molecular Formula
C10H13N2O12P3S • 4Na
Formula Weight
570.2
Purity
≥95% (a mixture of Rp and Sp isomers)
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N(C=C1C)[C@H]2CC[C@@H](COP([S-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O2)NC1=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H17N2O12P3S.4Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(22-8)5-21-27(20,28)24-26(18,19)23-25(15,16)17;;;;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,28)(H,11,13,14)(H2,15,16,17);;;;/q;4*+1/p-4/t7-,8+,27?;;;;/m0..../s1
InChi Key
XYBYCGHHJGEUNT-PPIYBXBVSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.4 mg

    $404

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    Product Description

    2',3'-Dideoxythymidine-5'-O-(1-thiotriphosphate) (ddTTP-α-S) is a sulfur-containing nucleoside triphosphate derivative. Thiol-containing dideoxynucleoside triphosphates (α-S-ddNTPs) incorporated into allele-specific primers prevent complete digestion by 5’-phosphodiesterase, which allows for alkylation and identification of SNP-containing alleles.1 ddTTP-α-S has been used for chain extension in PCR assays.2 ddTTP-α-S is a mixture of Rp and Sp isomers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sauer, S., Lechner, D., Berlin, K.D., et al. A novel procedure for efficient genotyping of single nucleotide polymorphisms. Nucleic Acids Res. 28(5), E13 (2000).

    2. Sauer, S., Lehrach, H., and Reinhardt, R. MALDI mass spectrometry analysis of single nucleotide polymorphisms by photocleavage and charge-tagging. Nucleic Acids Res. 31(11), e63 (2003).