A derivative of NAD+ and a synthetic intermediate
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7-deaza-8-bromo NAD+ (sodium salt)

Item No. 38479

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(aminocarbonyl)-1-[5-O-[hydroxy(phosphonooxy)phosphinyl]-β-D-ribofuranosyl]-pyridinium, P′→5′-ester with 6-bromo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, inner salt, monosodium salt
Synonyms
  • 7-deaza-8-bromo Nicotinamide adenine dinucleotide
Molecular Formula
C22H26BrN6O14P2 • Na
Formula Weight
763.3
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O[C@H]([C@@H]([C@H](O1)COP([O-])(OP([O-])(OC[C@H]([C@H]([C@H]2O)O)O[C@H]2[N+]3=CC(C(N)=O)=CC=C3)=O)=O)O)[C@@H]1N4C5=NC=NC(N)=C5C=C4Br.[Na+]
InChi Code
InChI=1S/C22H27BrN6O14P2.Na/c23-13-4-10-18(24)26-8-27-20(10)29(13)22-17(33)15(31)12(42-22)7-40-45(37,38)43-44(35,36)39-6-11-14(30)16(32)21(41-11)28-3-1-2-9(5-28)19(25)34;/h1-5,8,11-12,14-17,21-22,30-33H,6-7H2,(H5-,24,25,26,27,34,35,36,37,38);/q;+1/p-1/t11-,12-,14-,15-,16-,17-,21-,22-;/m1./s1
InChi Key
OPOPQTJXVPZBOJ-FGDZYNGESA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    700 µg

    $527

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    Product Description

    7-deaza-8-bromo NAD+ is a brominated and deazaadenine derivative of the signaling molecule and cofactor NAD+ (Item No. 16077).1 It has been used as a synthetic intermediate in the synthesis of cyclic and membrane-permeable diphosphate modulators of transient receptor potential melastatin 2 (TRPM2).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moreau, C., Kirchberger, T., Swarbrick, J.M., et al. Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: Rational design of antagonists. J. Med. Chem. 56(24), 10079-100102 (2013).