A derivative of NAD+
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Product Categories

Product Type

Biochemicals
Nucleotides/Nucleosides

8-ethylthio NAD+ (sodium salt)

Item No. 38483

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(ethylthio)-adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, monosodium salt
Synonyms
  • β-Nicotinamide-8-ethylthioadenine dinucleotide
  • 8-ethylthio Nicotinamide adenine dinucleotide
Molecular Formula
C23H30N7O14P2S • Na
Formula Weight
745.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H]([N+]3=CC=CC(C(N)=O)=C3)O2)([O-])=O)=O)O[C@H]1N4C(SCC)=NC5=C(N)N=CN=C54.[Na+]
InChi Code
InChI=1S/C23H31N7O14P2S.Na/c1-2-47-23-28-13-18(24)26-9-27-20(13)30(23)22-17(34)15(32)12(43-22)8-41-46(38,39)44-45(36,37)40-7-11-14(31)16(33)21(42-11)29-5-3-4-10(6-29)19(25)35;/h3-6,9,11-12,14-17,21-22,31-34H,2,7-8H2,1H3,(H5-,24,25,26,27,35,36,37,38,39);/q;+1/p-1/t11-,12-,14-,15-,16-,17-,21-,22-;/m1./s1
InChi Key
LTWCOMVZALZXPP-FGDZYNGESA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    700 µg

    $366

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    Product Description

    8-ethylthio NAD+ is a derivative of the signaling molecule and enzyme cofactor NAD+ (Item No. 16077).1 It has been used in the screening of analog-sensitive poly(ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gibson, B.A., Zhang, Y., Jiang, H., et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353(6294), 45-50 (2016).