A derivative of NAD+
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Synthetic Intermediates & Building Blocks

Research Area

8-methylamino NAD+ (sodium salt)

Item No. 38484

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(methylamino)-adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt, monosodium salt
Synonyms
  • 8-methylamino Nicotinamide adenine dinucleotide
  • β-Nicotinamide-8-methylaminoadenine dinucleotide
Molecular Formula
C22H29N8O14P2 • Na
Formula Weight
714.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP(OC[C@H]2O[C@@H]([N+]3=CC(C(N)=O)=CC=C3)[C@H](O)[C@@H]2O)([O-])=O)=O)O[C@H]1N4C(NC)=NC5=C(N)N=CN=C54.[Na+]
InChi Code
InChI=1S/C22H30N8O14P2.Na/c1-25-22-28-12-17(23)26-8-27-19(12)30(22)21-16(34)14(32)11(43-21)7-41-46(38,39)44-45(36,37)40-6-10-13(31)15(33)20(42-10)29-4-2-3-9(5-29)18(24)35;/h2-5,8,10-11,13-16,20-21,31-34H,6-7H2,1H3,(H6-,23,24,25,26,27,28,35,36,37,38,39);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1
InChi Key
FSPNYVDEUPLRMS-QYZPTAICSA-M
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    700 µg

    $447

    Add
    Product Description

    8-methylamino NAD+ is a derivative of the signaling molecule and enzyme cofactor NAD+ (Item No. 16077).1 It has been used in the screening of analog-sensitive poly(ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations. 8-methylamino NAD+ has also been used in the synthesis of cyclic ADP-ribose (cADPR) derivatives.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gibson, B.A., Zhang, Y., Jiang, H., et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353(6294), 45-50 (2016).

    2. Moreau, C., Ashamu, G.A., Bailey, V., et al. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: A C2' endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org. Biomol. Chem. 9(1), 278-290 (2011).