Fluorescent ATP derivatives
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (sodium salt)

Item No. 38546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′(or 3′)-(2-aminobenzoate) adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Synonyms
  • 2'(3')-ANT-ATP
Molecular Formula
C17H17N6O14P3 • 4Na
Formula Weight
714.2
Purity
≥95% (mixture of isomers)
Emission
428 nm
Excitation
330 nm
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1OC(C4=C(N)C=CC=C4)=O.O[C@@H]5[C@H](OC(C6=C(N)C=CC=C6)=O)[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@H]5N7C8=NC=NC(N)=C8N=C7.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/2C17H21N6O14P3.8Na/c18-9-4-2-1-3-8(9)17(25)35-13-10(5-33-39(29,30)37-40(31,32)36-38(26,27)28)34-16(12(13)24)23-7-22-11-14(19)20-6-21-15(11)23;18-9-4-2-1-3-8(9)17(25)35-13-12(24)10(5-33-39(29,30)37-40(31,32)36-38(26,27)28)34-16(13)23-7-22-11-14(19)20-6-21-15(11)23;;;;;;;;/h2*1-4,6-7,10,12-13,16,24H,5,18H2,(H,29,30)(H,31,32)(H2,19,20,21)(H2,26,27,28);;;;;;;;/q;;8*+1/p-8/t2*10-,12-,13-,16-;;;;;;;;/m11......../s1
InChi Key
AAJXMFALNYDRFR-HTDIHFSASA-F
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    3.1 mg

    $377

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and 3'-ANT-ATP are fluorescent ATP derivatives, which undergo spontaneous isomerization.1 2'(3')-ANT-ATP displays an emission maximum of 428 nm upon excitation at 330 nm in water.2 It inhibits mammalian adenylyl cyclase (AC1), AC2, and AC5 (Kis = 130, 640, and 120 nM, respectively), B. pertussis AC toxin CyaA (Kis = 1.3 and 20 µM, in the presence of manganese and magnesium, respectively), B. anthracis AC toxin edema factor (Kis = 0.44 and 5.15 µM in the presence of manganese and magnesium, respectively), and E. coli recombinase A (RecA; Ki = 6.3 µM).1,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinto, C., Lushington, G.H., Richter, M., et al. Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases. Biochem. Pharmacol. 82(4), 358-370 (2011).

    2. Hiratsuka, T. New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as substrates for various enzymes. Biochim. Biophys. Acta 742(3), 496-508 (1983).

    3. Göttle, M., Dove, S., Steindel, P., et al. Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides. Mol. Pharmacol. 72(3), 526-535 (2007).

    4. Taha, H.M., Schmidt, J., Göttle, M., et al. Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Mol. Pharmacol. 75(3), 693-703 (2009).

    5. Karasaki, Y., and Higashi, K. Inhibition of ATPase activity of the recA protein by ATP ribose-modified analogs. Arch. Biochem. Biophys. 233(2), 796-799 (1984).