A GTP derivative and bacterial GTPase inhibitor
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8-Bromoguanosine-5'-O-triphosphate (sodium salt)

Item No. 38551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((2R,3S,4R,5R)-5-(2-amino-8-bromo-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate, tetrasodium salt
Synonyms
  • 8-bromo GTP
Molecular Formula
C10H11BrN5O14P3 • 4Na
Formula Weight
690.0
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O[C@H]1N2C(Br)=NC3=C2NC(N)=NC3=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H15BrN5O14P3.4Na/c11-9-13-3-6(14-10(12)15-7(3)19)16(9)8-5(18)4(17)2(28-8)1-27-32(23,24)30-33(25,26)29-31(20,21)22;;;;/h2,4-5,8,17-18H,1H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19);;;;/q;4*+1/p-4/t2-,4-,5-,8-;;;;/m1..../s1
InChi Key
LHSZEDDOLBXHHW-QCYKBCJBSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    3 mg

    $253

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    Product Description

    8-Bromoguanosine-5'-O-triphosphate is a derivative of the energy substrate for protein synthesis and gluconeogenesis, guanosine 5'-triphosphate (GTP; Item No. 16060).1,2 It inhibits the E. coli GTPase FtsZ (Ki = 31.8 µM) but promotes the assembly of porcine brain microtubules in a cell-free assay when used at a concentration of 500 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Läppchen, T., Hartg, A.F., Pinas, V.A., et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry 44(21), 7879-7884 (2005).

    2. Muraoka, M., Fukuzawa, H., Nishida, A., et al. The effects of various GTP analogues on microtubule assembly. Cell Struct. Funct. 24(2), 101-109 (1999).