A nucelotide P2Y2 and P2Y4 receptor agonist
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Rp-Uridine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid, tetrasodium salt
Synonyms
  • Rp-UTP-α-S
Molecular Formula
C9H11N2O14P3S • 4Na
Formula Weight
588.1
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[S-][P@](OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=O)O1)(OP(OP([O-])([O-])=O)([O-])=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C9H15N2O14P3S.4Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(23-8)3-22-28(21,29)25-27(19,20)24-26(16,17)18;;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,29)(H,10,12,15)(H2,16,17,18);;;;/q;4*+1/p-4/t4-,6-,7-,8-,28-;;;;/m1..../s1
InChi Key
XACIVDFHPBUXKX-MCTGLJLHSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.5 mg

    $366

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    Product Description

    Rp-Uridine-5'-O-(1-thiotriphosphate) (Rp-UTP-α-S) is a nucleotide agonist of the purinergic P2Y2 and P2Y4 receptors.1. It induces inositol phosphate accumulation in 1321N1 astrocytoma cells expressing P2Y2 or P2Y4 receptors (EC50s = 5.4 and 27 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobson, K.A., Costanzi, S., Ivanov, A.A., et al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem. Pharmacol. 71(4), 540-549 (2006).