A fluorescent derivative of UTP
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Uridine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (sodium salt)

Item No. 38574

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]amino]-1-naphthalenesulfonic acid, P′′→5′-ester with uridine, trisodium salt
Synonyms
  • UTP-γ-AmNS
Molecular Formula
C19H19N3O17P3S • 3Na
Formula Weight
755.3
Purity
≥95%
Emission
465 nm
Excitation
360 nm
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[O-]P(NC1=CC=CC2=C1C=CC=C2S(O)(=O)=O)(OP([O-])(OP([O-])(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)N4C=CC(NC4=O)=O)=O)=O)=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C19H22N3O17P3S.3Na/c23-15-7-8-22(19(26)20-15)18-17(25)16(24)13(37-18)9-36-41(29,30)39-42(31,32)38-40(27,28)21-12-5-1-4-11-10(12)3-2-6-14(11)43(33,34)35;;;/h1-8,13,16-18,24-25H,9H2,(H,29,30)(H,31,32)(H,20,23,26)(H2,21,27,28)(H,33,34,35);;;/q;3*+1/p-3/t13-,16-,17-,18-;;;/m1.../s1
InChi Key
KUJZFGZITOCLQM-UFDLCCKLSA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    3.4 mg

    $646

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    Product Description

    Uridine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (UTP-γ-AmNS) is a fluorescent derivative of the nucleotide and dual purinergic P2Y2 and P2Y4 receptor agonist UTP (Item No. 9003530).1 It has been used in high-throughput screening (HTS) assays for inhibitors of bacterial RNA polymerase activity. Upon incorporation of UMP in RNA, γ-AmNS-PPi is released, which has an emission at 465 nm upon excitation at 360 nm and a higher fluorescence intensity than UTP-γ-AmNS.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhat, J., Rane, R.A., Solapure, S.M., et al. High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog. J. Biomol. Screen. 11(8), 968-976 (2006).