An ionizable cationic amino lipid
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Lipid 14

Item No. 38589

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate)
CAS Number
2430034-05-0
Molecular Formula
C56H110N2O6
Formula Weight
907.5
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: SolubleMethyl Acetate: 25 mg/ml
SMILES
O=C(OCCCCCCCCN(CCOC(CCCN(C)C)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)C(CCCCCC)CCCCCCCC
InChi Code
InChI=1S/C56H110N2O6/c1-7-11-15-19-25-33-42-52(40-31-17-13-9-3)55(60)63-49-37-29-23-21-27-35-46-58(48-51-62-54(59)44-39-45-57(5)6)47-36-28-22-24-30-38-50-64-56(61)53(41-32-18-14-10-4)43-34-26-20-16-12-8-2/h52-53H,7-51H2,1-6H3
InChi Key
NGUVKPMCPAGUDU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $304

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    10 mg

    $456

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    25 mg

    $834

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    50 mg

    $1,213

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    Cayman Chemical
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    Product Description

    Lipid 14 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing lipid 14 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface glycoprotein RBD, increase anti-RBD antibody levels in mice, as well as increase the number of isolated mouse splenocytes secreting IFN-γ and IL-2, but not IL-4 or IL-10, when incubated with the SARS-CoV-2 spike glycoprotein. LNPs containing lipid 14 and encapsulating mRNA encoding the bacterial Caf1 (F1) capsule antigen from Y. pestis, the bacteria that causes bubonic plague, induces anti-F1 cellular and humoral responses and protects against lethal Y. pestis infection in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elia, U., Ramishetti, S., Rosenfeld, R., et al. Design of SARS-CoV-2 hFc-conjugated receptor-binding domain mRNA vaccine delivered via lipid nanoparticles. ACS Nano 15(6), 9627-9637 (2021).

    2. Kon, E., Levy, Y., Elia, U., et al. A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium. Sci. Adv. 9(10), eadg1036 (2023).