A biotinylated PUFA
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Unmodified Version(s)
3861013(S)-HODE
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13(S)-HODE-biotin

Item No. 38612

Technical Information
Formal Name
13(S)-hydroxy-N'-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)octadeca-9Z,11E-dienehydrazide
CAS Number
1217458-58-6
Molecular Formula
C28H48N4O4S
Formula Weight
Purity
≥98% (may contain trace amounts of free biotin)
A 1 mg/ml solution in ethanol
DMF: >10 mg/mlDMSO: >10 mg/mlEthanol: >10 mg/mlPBS (pH 7.2): ~100 µg/ml
λmax
234 nm
SMILES
CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(N([H])N([H])C(CCCC[C@@H]1SC[C@@]2([H])[C@]1([H])N([H])C(N2[H])=O)=O)=O
InChi Code
InChI=1S/C28H48N4O4S/c1-2-3-11-16-22(33)17-12-9-7-5-4-6-8-10-13-19-25(34)31-32-26(35)20-15-14-18-24-27-23(21-37-24)29-28(36)30-27/h7,9,12,17,22-24,27,33H,2-6,8,10-11,13-16,18-21H2,1H3,(H,31,34)(H,32,35)(H2,29,30,36)/b9-7-,17-12+/t22-,23-,24-,27-/m0/s1
InChi Key
VGSREJALHGALEV-YJERLKHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    13(S)-HODE is the lipoxygenase metabolite of linoleic acid. 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.1 The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or receptors that specifically bind 15(S)-HETE provides a basis for similar use of 13(S)-HODE-biotin.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van de Velde, M.J., Engels, F., Henricks, P.A.J., et al13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells. J. Leukoc. Biol. 56, 200-202 (1994).

    2. Kang, L.T., and Vanderhoek, J.Y. Synthesis and use of a novel biotinylated probe for the chemiluminescent detection of proteins that bind 15-hydroxyeicosatetraenoic acid. Anal. Biochem. 250(1), 119-122 (1997).