A SERT-nNOS protein-protein interaction inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ZZL-7

Item No. 38645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-alanyl-L-valine, methyl ester
CAS Number
99141-91-0
Synonyms
  • Ac-Ala-Val-OMe
  • Methyl acetyl-L-alanyl-L-valinate
Molecular Formula
C11H20N2O4
Formula Weight
244.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC([C@H](NC([C@@H](NC(C)=O)C)=O)C(OC)=O)C
InChi Code
InChI=1S/C11H20N2O4/c1-6(2)9(11(16)17-5)13-10(15)7(3)12-8(4)14/h6-7,9H,1-5H3,(H,12,14)(H,13,15)/t7-,9-/m0/s1
InChi Key
RHDUVXUSBMPQOK-CBAPKCEASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $63

    Add

    10 mg

    $99

    Add

    25 mg

    $217

    Add

    50 mg

    $371

    Add
    Product Description

    ZZL-7 is an inhibitor of the protein-protein interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS).1 It increases in vivo serotonergic neuron firing in SERT-Cre transgenic mice, which have reduced SERT levels, when administered at a dose of 10 mg/kg. ZZL-7 (20 and 40 mg/kg) reduces immobility time in the tail suspension test and forced swim test in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, N., Qin, Y.-J., Xu, C., et al. Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN. Science 378(6618), 390-398 (2022).