An ionizable cationic lipidoid
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AA-T3A-C12

Item No. 38648

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-(bis(3-(bis(2-hydroxydodecyl)amino)propyl)amino)propyl)-4-methoxybenzamide
CAS Number
2938207-23-7
Molecular Formula
C65H126N4O6
Formula Weight
1059.7
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
λmax
254 nm
SMILES
O=C(C1=CC=C(OC)C=C1)NCCCN(CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC
InChi Code
InChI=1S/C65H126N4O6/c1-6-10-14-18-22-26-30-34-41-60(70)55-68(56-61(71)42-35-31-27-23-19-15-11-7-2)53-39-51-67(50-38-49-66-65(74)59-45-47-64(75-5)48-46-59)52-40-54-69(57-62(72)43-36-32-28-24-20-16-12-8-3)58-63(73)44-37-33-29-25-21-17-13-9-4/h45-48,60-63,70-73H,6-44,49-58H2,1-5H3,(H,66,74)
InChi Key
ADWWRKPNPJUOGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    AA-T3A-C12 is an ionizable cationic lipidoid that contains a polyamine core, tethered to the sigma receptor ligand anisamide, and four 12-carbon tails.1 It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing AA-T3A-C12 and encapsulating siRNA for Hsp47, a molecular chaperone whose expression is increased in liver fibrosis, reduce the expression of Hsp47 in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells, which both express high levels of the sigma receptor. LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce liver fibrosis induced by carbon tetrachloride (CCl4) in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, X., Gong, N., Xue, L., et al. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nat. Commun. 14(1), 75 (2023).