An isomer of dCTP-α-S
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Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-cytidine 5′→P′′-ester with [P′′(S)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Synonyms
  • Sp-dCTP-α-S
Molecular Formula
C9H12N3O12P3S • 4Na
Formula Weight
571.1
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H](C1)[C@H](O[C@H]1N2C=CC(N)=NC2=O)CO[P@@](OP([O-])(OP([O-])([O-])=O)=O)([S-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C9H16N3O12P3S.4Na/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(22-8)4-21-27(20,28)24-26(18,19)23-25(15,16)17;;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,28)(H2,10,11,14)(H2,15,16,17);;;;/q;4*+1/p-4/t5-,6+,8+,27-;;;;/m0..../s1
InChi Key
NELHAJNNDVTQIM-LYZAKFEESA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.4 mg

    $392

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    Product Description

    Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S) is an isomer of the sulfur-containing nucleotide derivative dCTP-α-S.1 It inhibits deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Ki = 6.3 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morris, E.R., Kunzelmann, S., Caswell, S.J., et al. Probing the catalytic mechanism and inhibition of SAMHD1 using the differential properties of Rp- and Sp-dNTPαS diastereomers. Biochemistry 60(21), 1682-1698 (2021).