A fluorescent nucleotide derivative
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2'-Deoxy-3'-O-(N'-methylanthraniloyl)adenosine-5'-O-diphosphate (sodium salt)

Item No. 38670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-3′-[2-(methylamino)benzoate] adenosine 5′-(trihydrogen diphosphate), trisodium salt
Synonyms
  • 2'-deoxy-3'-MANT-ADP
  • MANT-dADP
Molecular Formula
C18H19N6O10P2 • 3Na
Formula Weight
610.3
Purity
≥95%
Emission
453 nm
Excitation
356 nm
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[O-]P(OP(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C32)C[C@@H]1OC(C4=C(NC)C=CC=C4)=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C18H22N6O10P2.3Na/c1-20-11-5-3-2-4-10(11)18(25)33-12-6-14(24-9-23-15-16(19)21-8-22-17(15)24)32-13(12)7-31-36(29,30)34-35(26,27)28;;;/h2-5,8-9,12-14,20H,6-7H2,1H3,(H,29,30)(H2,19,21,22)(H2,26,27,28);;;/q;3*+1/p-3/t12-,13+,14+;;;/m0.../s1
InChi Key
CDANSGCALQQNSD-JNFDPCJISA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    2.7 mg

    $366

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    Product Description

    2'-Deoxy-3'-O-(N'-methylanthraniloyl)adenosine-5'-O-diphosphate (MANT-dADP) is a fluorescent nucleotide derivative.1 It displays an emission maximum of 453 nm upon excitation at 350 nm.1 MANT-dADP (100 µM) decreases inositol phosphate formation in CHO-K1 cells expressing the human purinergic P2Y12 receptor.2 It has been used to study the interaction between cardiac troponin I and myofibrils.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bujalowski, W., and Klonowska, M.M. Structural characteristics of the nucleotide-binding site of Escherichia coli primary replicative helicase DnaB protein. Studies with ribose and base-modified fluorescent nucleotide analogs. Biochemistry 33(15), 4682-4694 (1994).

    2. Schmidt, P., Ritscher, L., Dong, E.N., et al. Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12. Mol. Pharmacol. 83(1), 256-266 (2013).

    3. Gunther, L.K., Feng, H.-Z., Wei, H., et al. Effect of N-terminal extension of cardiac troponin I on the Ca2+ regulation of ATP binding and ADP dissociation of myosin II in native cardiac myofibrils. Biochemistry 55(12), 1887-1897 (2016).