An isomer of dUTP-α-S and a P2Y2 receptor agonist
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Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (sodium salt)

Item No. 38671

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-uridine 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)), tetrasodium salt
Synonyms
  • Rp-dUTP-α-S
Molecular Formula
C9H11N2O13P3S • 4Na
Formula Weight
572.1
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H](C1)[C@H](O[C@H]1N2C=CC(NC2=O)=O)CO[P@](OP([O-])(OP([O-])([O-])=O)=O)([S-])=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C9H15N2O13P3S.4Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)22-6(5)4-21-27(20,28)24-26(18,19)23-25(15,16)17;;;;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,28)(H,10,13,14)(H2,15,16,17);;;;/q;4*+1/p-4/t5-,6+,8+,27+;;;;/m0..../s1
InChi Key
WEURFJRVAQNWAA-BTLCXKTLSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.4 mg

    $426

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    Product Description

    Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S) is an isomer of the sulfur-containing nucleotide dUTP-α-S and an agonist of the purinergic P2Y2 receptor.1 It selectively induces inositol phosphate accumulation in 1321N1 astrocytoma cells expressing P2Y2 receptors (EC50 = 12.5 µM) over P2Y4-expressing 1321N1 cells at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobson, K.A., Costanzi, S., Ivanov, A.A., et al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem. Pharmacol. 71(4), 540-549 (2006).