A fluorescent derivative of GTP
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Guanosine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (sodium salt)

Item No. 38687

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P′→P-anhydride with 5-(phosphonoamino)-1-naphthalenesulfonic acid guanosine 5′-(trihydrogen diphosphate), trisodium salt
Synonyms
  • GTP-γ-AmNS
Molecular Formula
C20H20N6O16P3S • 3Na
Formula Weight
794.4
Purity
≥95%
Emission
460 nm
Excitation
340 nm
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=S(O)(C1=CC=CC2=C1C=CC=C2NP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(NC(N)=NC5=O)=C5N=C4)O3)([O-])=O)([O-])=O)([O-])=O)=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C20H23N6O16P3S.3Na/c21-20-23-17-14(18(29)24-20)22-8-26(17)19-16(28)15(27)12(40-19)7-39-44(32,33)42-45(34,35)41-43(30,31)25-11-5-1-4-10-9(11)3-2-6-13(10)46(36,37)38;;;/h1-6,8,12,15-16,19,27-28H,7H2,(H,32,33)(H,34,35)(H2,25,30,31)(H,36,37,38)(H3,21,23,24,29);;;/q;3*+1/p-3/t12-,15-,16-,19-;;;/m1.../s1
InChi Key
JQZUGWUTHYEVOQ-LXFLRVHDSA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    3.6 mg

    $534

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    Product Description

    Guanosine-5'-O-triphosphoro-γ-1-(5-sulfonic acid)naphthylamidate (GTP-γ-AmNS) is a fluorescent derivative of GTP (Item No. 16060).1,2 It has been used as a substrate for snake venom phosphodiesterases (PDEs) and to monitor tubulin assembly in cell-free assays. GTP-γ-AmNS diplays an emission maximum of 444 nm upon excitation at 320 nm, which is quenched by 1.2-1.4-fold upon cleavage of the α-β phosphoryl bond.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pollack, S.E., and Auld, D.S. Fluorescent nucleotide triphosphate substrates for snake venom phosphodiesterase. Anal. Biochem. 127(1), 81-88 (1982).

    2. Yarbrough, L.R., and Kirsch, M. Binding of fluorescent analogs of GTP to the exchangeable nucleotide binding site of tubulin. The Journal of Biological Chemisty 256(1), 112-117 (1981).