An ionizable cationic lipid
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Lipid 10

Item No. 38705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-1-piperazinepropanoic acid, 2-[di-(9Z,12Z)-9,12-octadecadien-1-ylamino]ethyl ester
CAS Number
2430034-02-7
Synonyms
  • EA-PIP
Molecular Formula
C46H85N3O2
Formula Weight
712.2
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: 25 mg/ml
SMILES
CN1CCN(CCC(OCCN(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)=O)CC1
InChi Code
InChI=1S/C46H85N3O2/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-37-48(44-45-51-46(50)36-39-49-42-40-47(3)41-43-49)38-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h12-15,18-21H,4-11,16-17,22-45H2,1-3H3/b14-12-,15-13-,20-18-,21-19-
InChi Key
OVVLEZAQIGEEPO-QYCRHRGJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $207

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    25 mg

    $382

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    Cayman Chemical
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    Product Description

    Lipid 10 is an ionizable cationic lipid (pKa = 6.2-6.5).1 Lipid nanoparticles (LNPs) containing lipid 10 and encapsulating siRNA for the gene encoding cytoskeleton-associated protein 5 (CKAP5) reduce its gene expression and protein levels in vitro and selectively reduce cell viability in a variety of genetically unstable cancer cell lines.2 Administration of LNPs containing lipid 10 and encapsulating CKAP5 siRNA reduce tumor growth and increase survival in an NCI/ADR-RES human ovarian cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ramishetti, S., Hazan-Halevy, I., Chatterjee, S., et al. A combinatorial library of lipid nanoparticles for RNA delivery to leukocytes. Adv. Mater. 32(12), e1906128 (2020).

    2. Chatterjee, S., Naidu, G.S., Hazan-Halevy, I., et al. Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells. Sci. Adv. 9(14), eade4800 (2023).