A STING agonist
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STING Agonist D61

Item No. 38706

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1-[3-fluoromethyl)phenyl]-2-oxazolyl]amino]propyl]
CAS Number
2850251-27-1
Synonyms
  • D61
  • Stimulator of Interferon Genes Agonist D61
Molecular Formula
C29H29F3N8O4
Formula Weight
610.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
λmax
322 nm
SMILES
COC1=C2C(N=C(NC(C3=CC(C)=NN3CC)=O)N2CCCNC4=NC=C(C5=C(C(F)(F)F)C=CC=C5)O4)=CC(C(N)=O)=C1
InChi Code
InChI=1S/C29H29F3N8O4/c1-4-40-21(12-16(2)38-40)26(42)37-27-36-20-13-17(25(33)41)14-22(43-3)24(20)39(27)11-7-10-34-28-35-15-23(44-28)18-8-5-6-9-19(18)29(30,31)32/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H2,33,41)(H,34,35)(H,36,37,42)
InChi Key
SAIPDXPIJPBWOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-β-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the expression of mRNA encoding IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) and phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. In vivo, D61 (0.25 mg/kg every other day) reduces tumor volume without affecting body weight in a CT26 murine colon cancer model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, N.-N., Zhang, H., Zhu, Q.-S., et al. Development of orally bioavailable amidobenzimidazole analogues targeting stimulator of interferon gene (STING) receptor. J. Med. Chem. 66(8), 5584-5610 (2023).