A radiation sensitizer
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Product Type

Biochemicals

Research Area

Cancer

Borofalan

Item No. 38760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(borono-10B)-L-phenylalanine
CAS Number
80994-59-8
Synonyms
  • Boronophenylalanine B-10
  • 10B-L-BPA
Molecular Formula
C9H12[10B]NO4
Formula Weight
208.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
N[C@H](C(O)=O)CC(C=C1)=CC=C1[10B](O)O
InChi Code
InChI=1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1/i10-1
InChi Key
NFIVJOSXJDORSP-ULMHTEDTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $290

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    10 mg

    $537

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    25 mg

    $825

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    Cayman Chemical
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    Product Description

    Borofalan is a radiation sensitizer that contains 10B, a stable isotope of boron.1 It sensitizes B16/F10 melanoma cells to fast and thermal neutron radiation when used at a concentration of 50 µg/ml. Borofalan (300 mg/kg) selectively accumulates in sarcoma tissues over blood, muscle, skin, liver, and brain tissue in rats.2 In vivo, borofalan (803 mg/kg), in combination with radiation, increases mean survival time in an F98 rat glioma model.3 Formulations containing borofalan have been used in boron neutron capture therapy (BNCT) of unresectable, locally recurrent head and neck cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ichihashi, M., Shiono, M., Yamamura, K., et al. In vitro radiobiological analysis of 10B-L-BPA for BNCT of malignant melanoma: Correlation of determined 10B-content and cell killing effect. Pigment Cell Res. Suppl. 2, 193-198 (1992).

    2. Pignol, J.P., Oudart, H., Chauvel, P., et al. Selective delivery of 10B to soft tissue sarcoma using 10B-L-borophenylalanine for boron neutron capture therapy. Br. J. Radiol. 71(843), 320-323 (1998).

    3. Matalka, K.Z., Barth, R.F., Staubus, A.E., et al. Neutron capture therapy of a rat glioma using boronophenylalanine as a capture agent. Radiat. Res. 137(1), 44-51 (1994).