An androgen receptor agonist
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LGD 2226

Item No. 38764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone
CAS Number
328947-93-9
Molecular Formula
C14H9F9N2O
Formula Weight
392.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1C=C(C(F)(F)F)C2=C(N1)C=CC(N(CC(F)(F)F)CC(F)(F)F)=C2
InChi Code
InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26)
InChi Key
ULBPQWIGZUGPHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $43

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    5 mg

    $194

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    10 mg

    $344

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    25 mg

    $752

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    Product Description

    LGD 2226 is an androgen receptor agonist.1 It induces reporter activation in a reporter assay using CV-1 cells expressing human androgen receptors (EC50 = 0.2 nM). LGD 2226 (10 mg/kg per day) increases prostate and levator ani muscle weight in orchidectomized (ORDX) rats.2 It increases bone mineral density and breaking strength and decreases periosteal mineral apposition and bone formation rates in ORDX rats when administered at doses of 3 or 10 mg/kg per day. LGD 2226 increases mounting behavior and the number of intromissions and ejaculations in ORDX rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Oeveren, A., Motamedi, M., Mani, N.S., et al. Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. J. Med. Chem. 49(21), 6143-6146 (2006).

    2. Miner, J.N., Chang, W., Chapman, M.S., et al. An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology 148(1), 363-373 (2007).