A cytidine deaminase inhibitor
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Cedazuridine

Item No. 38767

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-2′-deoxy-2′,2′-difluoro-3,4,5,6-tetrahydro-uridine
CAS Number
1141397-80-9
Synonyms
  • E7727
Molecular Formula
C9H14F2N2O5
Formula Weight
268.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
FC1([C@H](N2C(N[C@@H](CC2)O)=O)O[C@@H]([C@H]1O)CO)F
InChi Code
InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1
InChi Key
VUDZSIYXZUYWSC-DBRKOABJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $128

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    10 mg

    $225

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    25 mg

    $492

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    Product Description

    Cedazuridine is an inhibitor of cytidine deaminase (IC50 = 0.4 µM).1 It increases plasma levels of decitabine via inhibition of its metabolism by cytidine deaminase in rhesus monkeys when administered at doses of 1 and 10 mg/kg. Cedazuridine (3 mg/kg) induces decreases in leukemic cell expansion in combination with orally administered 5-azacytidine (Item No. 11164), which is inactive as a single agent, in the bone marrow and spleen in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.2 Formulations containing cedazuridine in combination with decitabine have been used in the treatment of myelodysplastic syndrome (MDS).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ferraris, D., Duvall, B., Delahanty, G., et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J. Med. Chem. 57(6), 2582-2588 (2014).

    2. Ramsey, H.E., Oganesian, A., Gorska, A.E., et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Target Oncol. 15(2), 231-240 (2020).