A SHP-2 inhibitor
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RMC-4630

Item No. 38772

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(2-amino-3-chloro-4-pyridinyl)thio]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-5-methyl-2-pyrazinemethanol
CAS Number
2172652-48-9
Synonyms
  • SAR442720
Molecular Formula
C20H27ClN6O2S
Formula Weight
451.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly SolubleDMSO: SolubleWater: Slightly Soluble
SMILES
N[C@H]1C2(CO[C@H]1C)CCN(C3=NC(C)=C(N=C3CO)SC4=CC=NC(N)=C4Cl)CC2
InChi Code
InChI=1S/C20H27ClN6O2S/c1-11-19(30-14-3-6-24-17(23)15(14)21)26-13(9-28)18(25-11)27-7-4-20(5-8-27)10-29-12(2)16(20)22/h3,6,12,16,28H,4-5,7-10,22H2,1-2H3,(H2,23,24)/t12-,16+/m0/s1
InChi Key
HISJAYUQVHMWTA-BLLLJJGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $50

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    1 mg

    $95

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    5 mg

    $396

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    10 mg

    $743

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    Product Description

    RMC-4630 is an allosteric inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jogalekar, A., Won, W., Koltun, E.S., et al. 2,5-Disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric SHP2 inhibitors. WO2018013597A1, (2018).

    2. Smith, J.A., Singh, M., Nichols, R.J., et al. Abstract 1943: SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway. Cancer Res. 80(16 Suppl), 1943 (2020).