A Nampt inhibitor
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OT-82

Item No. 38782

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-(4-pyridinyl)-benzamide
CAS Number
1800487-55-1
Molecular Formula
C26H21FN4O
Formula Weight
424.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C1=CC(C#CC2=CC=C(C=C2)F)=C(C3=CC=NC=C3)C=C1)NCCCC4=CNN=C4
InChi Code
InChI=1S/C26H21FN4O/c27-24-8-4-19(5-9-24)3-6-22-16-23(7-10-25(22)21-11-14-28-15-12-21)26(32)29-13-1-2-20-17-30-31-18-20/h4-5,7-12,14-18H,1-2,13H2,(H,29,32)(H,30,31)
InChi Key
CEPAXRIKSUXHHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $115

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    5 mg

    $288

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    Cayman Chemical
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    Product Description

    OT-82 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor.1 It inhibits recombinant human and recombinant mouse Nampt in a cell-free assay when used at concentrations ranging from 0.1 to 10 µM. OT-82 is cytotoxic against a panel of 12 hematological cancer cells (IC50s = 1.01-5.64 nM). In vivo, OT-82 (25 and 50 mg/kg) increases survival and decreases tumor volume in MV4-11 and HEL 92.1.7 mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Korotchkina, L., Kazyulkin, D., Komarov, P.G., et al. OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis. Leukemia 34(7), 1828-1839 (2020).