A polyamine branched-chain lipidoid
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C12-SPM

Item No. 38784

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
13,17,22,26-tetrakis(2-hydroxydodecyl)-13,17,22,26-tetraazaoctatriacontane-11,28-diol
CAS Number
2055647-81-7
Synonyms
  • C12-Spermine
Molecular Formula
C82H170N4O6
Formula Weight
1308.3
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
SMILES
CCCCCCCCCCC(O)CN(CC(O)CCCCCCCCCC)CCCN(CC(O)CCCCCCCCCC)CCCCN(CC(O)CCCCCCCCCC)CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC
InChi Code
InChI=1S/C82H170N4O6/c1-7-13-19-25-31-37-43-49-59-77(87)71-83(67-57-69-85(73-79(89)61-51-45-39-33-27-21-15-9-3)74-80(90)62-52-46-40-34-28-22-16-10-4)65-55-56-66-84(72-78(88)60-50-44-38-32-26-20-14-8-2)68-58-70-86(75-81(91)63-53-47-41-35-29-23-17-11-5)76-82(92)64-54-48-42-36-30-24-18-12-6/h77-82,87-92H,7-76H2,1-6H3
InChi Key
UUNYZGWXRRFHOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $112

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    10 mg

    $201

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    25 mg

    $445

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    Product Description

    C12-SPM is a polyamine branched-chain lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA targeting the host protein kinase protein kinase C-related kinase 2 (PRK2) to inhibit hepatitis C virus (HCV) replication in Huh7 cells and a mouse model of HCV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, H.-J., Jeon, E.J., Lee, J.S., et al. Galactosylated lipidoid nanoparticles for delivery of small interfering RNA to inhibit hepatitis C viral replication in vivo. Adv. Healthc. Mater. 5(22), 2931-2941 (2016).