An ago-PAM of α7 nAChRs
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

B-973B

Item No. 38790

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]-benzenepropanamide
CAS Number
2244989-34-0
Synonyms
  • (–)-(S)-B-973B
Molecular Formula
C24H26F2N6O
Formula Weight
452.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
FC(C=C1CCC(N[C@H](C2=CN=CC(N3CCN(C4=CC=CC=N4)CC3)=N2)C)=O)=C(C=C1)F
InChi Code
InChI=1S/C24H26F2N6O/c1-17(29-24(33)8-6-18-5-7-19(25)20(26)14-18)21-15-27-16-23(30-21)32-12-10-31(11-13-32)22-4-2-3-9-28-22/h2-5,7,9,14-17H,6,8,10-13H2,1H3,(H,29,33)/t17-/m0/s1
InChi Key
WQYZERNSONBUCW-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $174

    Add

    10 mg

    $308

    Add

    25 mg

    $675

    Add
    Product Description

    B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of α7 nicotinic acetylcholine receptors (nAChRs).1,2 It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human α7 nAChR when used at a concentration of 10 µM.2 B-973B (10 mg/kg) decreases paw edema and induces antinociception in the first and second phase of the formalin test in a mouse model of inflammatory pain. It also inhibits tau aggregation induced by seeding with insoluble human tau isolated from a patient with Alzheimer’s disease in primary rat neurons in a concentration-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Post-Munson, D.J., Pieschl, R.L., Molski, T.F., et al. B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor. Eur. J. Pharmacol. 799, 16-25 (2017).

    2. Garai, S., Raja, K.S., Papke, R.L., et al. B-973, a novel α7 nAChR Ago-PAM: Racemic and asymmetric synthesis, electrophysiological studies, and in vivo evaluation. ACS Med. Chem. Lett. 9(11), 1144-1148 (2018).

    3. Gibbons, G.S., Gould, H., Lee, V.M.-Y., et al. Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model. The Journal of Biological Chemisty 299(7), 104876 (2023).