A prodrug form of CHS-828
Related Products
Active Metabolite(s)
11021CHS-828
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GMX1777

Item No. 38798

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[[6-(4-chlorophenoxy)hexyl]imino](cyanoamino)methyl]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-pyridinium, monochloride
CAS Number
432037-57-5
Synonyms
  • EB1627
  • Teglarinad
Molecular Formula
C30H43ClN5O8 • Cl
Formula Weight
672.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
N#CNC(NCCCCCCOC1=CC=C(C=C1)Cl)=NC2=CC=[N+](COC(OCCOCCOCCOCCOC)=O)C=C2.[Cl-]
InChi Code
InChI=1S/C30H42ClN5O8.ClH/c1-38-16-17-39-18-19-40-20-21-41-22-23-43-30(37)44-25-36-13-10-27(11-14-36)35-29(34-24-32)33-12-4-2-3-5-15-42-28-8-6-26(31)7-9-28;/h6-11,13-14H,2-5,12,15-23,25H2,1H3,(H,33,34);1H
InChi Key
DAHMXVAETAAQOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $112

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    5 mg

    $501

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    Product Description

    GMX1777 is a prodrug form of the nicotinamide phosphoribosyltransferase (Nampt) inhibitor CHS-828 (Item No. 11021).1 Intravenous administration of GMX1777 (75 and 150 mg/kg) reduces NAD+ levels in tumors, but not muscle tissue, in a DMS 273 lung cancer mouse xenograft model. GMX1777 (50 mg/kg per day), in combination with radiation, decreases tumor diameter and microvessel density in C666-1 nasopharyngeal and FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beauparlant, P., Bédard, D., Bernier, C., et al. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs 20(5), 346-354 (2009).

    2. Kato, H., Ito, E., Alajez, N.M., et al. Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma. Clin. Cancer Res. 16(3), 898-911 (2010).