A peptide fragment of surfactant protein A
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SP-A (196-215) (human) (trifluoroacetate salt)

Item No. 38838

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • SPA4
  • Surfactant Protein A
Molecular Formula
C107H145N29O35 • XCF3COOH
Formula Weight
2397.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
GDFRYSDGTPVNYTNWYRGE-OH
Solubility(Learn about Variance in Solubility)
10% ACN/H2O: Soluble
SMILES
[H]NCC(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CC7=CC=CC=C7)=O)CC(O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C107H145N29O35.C2HF3O2/c1-51(2)86(134-101(166)77-19-12-36-136(77)104(169)88(53(4)139)133-82(147)49-119-90(155)74(44-84(150)151)129-100(165)76(50-137)132-94(159)69(39-56-22-28-60(141)29-23-56)124-91(156)65(18-11-35-116-107(113)114)123-93(158)67(37-54-13-6-5-7-14-54)126-98(163)75(45-85(152)153)121-80(145)46-108)102(167)130-72(42-78(109)143)96(161)127-70(40-57-24-30-61(142)31-25-57)99(164)135-87(52(3)138)103(168)131-73(43-79(110)144)97(162)128-71(41-58-47-117-63-16-9-8-15-62(58)63)95(160)125-68(38-55-20-26-59(140)27-21-55)92(157)122-64(17-10-34-115-106(111)112)89(154)118-48-81(146)120-66(105(170)171)32-33-83(148)149;3-2(4,5)1(6)7/h5-9,13-16,20-31,47,51-53,64-77,86-88,117,137-142H,10-12,17-19,32-46,48-50,108H2,1-4H3,(H2,109,143)(H2,110,144)(H,118,154)(H,119,155)(H,120,146)(H,121,145)(H,122,157)(H,123,158)(H,124,156)(H,125,160)(H,126,163)(H,127,161)(H,128,162)(H,129,165)(H,130,167)(H,131,168)(H,132,159)(H,133,147)(H,134,166)(H,135,164)(H,148,149)(H,150,151)(H,152,153)(H,170,171)(H4,111,112,115)(H4,113,114,116);(H,6,7)/t52-,53-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,86+,87+,88+;/m1./s1
InChi Key
CZDMBPXUDOGJGY-GEARQURQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    Surfactant protein A (SP-A) (196-215) is a synthetic peptide that corresponds to amino acids 196-215 of the C-terminal carbohydrate recognition domain of human SP-A.1 It inhibits LPS-induced TNF-α release in JAWSII mouse dendritic cells when used at concentrations of 1 and 10 µM. SP-A (196-215) (75 µM) induces phagocytosis of P. aeruginosa by JAWSII cells.2 Intratracheal administration of SP-A (196-215) (50 µg/animal) decreases disease severity and lung colony forming units in a mouse model of P. aeruginosa infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Awasthi, S., Brown, K., King, C., et al. A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-α release from mouse JAWS II dendritic cells. J. Pharmacol. Exp. Ther. 336(3), 672-681 (2011).

    2. Awasthi, S., Singh, B., Ramani, V., et al. TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection. PLoS One 14(1), e0210979 (2019).