A peptide inhibitor of the NDRG2-PPM1A protein-protein interaction
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Tat-QFNP12 (trifluoroacetate salt)

Item No. 38845

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-valyl-L-lysyl-L-lysyl-L-glutamyl-L-alanyl-L-glutamyl-L-leucyl-L-aspartyl-L-lysyl-L-tyrosyl-L-leucyl-L-glutamic acid, trifluoroacetate salt
Molecular Formula
C130H225N47O35 • XCF3COOH
Formula Weight
3006.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
YGRKKRRQRRRVKKEAELDKYLE-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)CC(O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C130H225N47O35.C2HF3O2/c1-68(2)62-92(119(206)172-91(124(211)212)46-50-100(186)187)174-121(208)94(65-73-37-41-75(179)42-38-73)175-115(202)81(27-11-16-54-134)168-122(209)95(66-101(188)189)176-120(207)93(63-69(3)4)173-117(204)90(45-49-99(184)185)159-103(190)71(7)157-105(192)89(44-48-98(182)183)170-109(196)80(26-10-15-53-133)162-110(197)82(28-12-17-55-135)171-123(210)102(70(5)6)177-118(205)87(34-23-61-155-130(148)149)167-113(200)84(31-20-58-152-127(142)143)164-112(199)85(32-21-59-153-128(144)145)166-116(203)88(43-47-96(137)180)169-114(201)86(33-22-60-154-129(146)147)165-111(198)83(30-19-57-151-126(140)141)163-108(195)79(25-9-14-52-132)161-107(194)78(24-8-13-51-131)160-106(193)77(29-18-56-150-125(138)139)158-97(181)67-156-104(191)76(136)64-72-35-39-74(178)40-36-72;3-2(4,5)1(6)7/h35-42,68-71,76-95,102,178-179H,8-34,43-67,131-136H2,1-7H3,(H2,137,180)(H,156,191)(H,157,192)(H,158,181)(H,159,190)(H,160,193)(H,161,194)(H,162,197)(H,163,195)(H,164,199)(H,165,198)(H,166,203)(H,167,200)(H,168,209)(H,169,201)(H,170,196)(H,171,210)(H,172,206)(H,173,204)(H,174,208)(H,175,202)(H,176,207)(H,177,205)(H,182,183)(H,184,185)(H,186,187)(H,188,189)(H,211,212)(H4,138,139,150)(H4,140,141,151)(H4,142,143,152)(H4,144,145,153)(H4,146,147,154)(H4,148,149,155);(H,6,7)/t71-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,102-;/m0./s1
InChi Key
HGSZFZKCQOQXHA-UIIMPUMGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Tat-QFNP12 is a peptide containing a transcriptional transactivator (Tat) transmembrane domain and an inhibitor of the protein-protein interaction between N-Myc downstream regulated gene 2 (NDRG2) and the protein phosphatase Mg2+/Mn2+ dependent 1A (PPM1A).1 It decreases the loss of blood-brain barrier endothelial tight junctions induced by increased levels of matrix metalloproteinase-9 (MMP-9), reduces cerebral edema, as well as increases spontaneous activity and symmetry of limb movement, in an endovascular puncture-induced mouse model of subarachnoid hemorrhage when administered at a dose of 20 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, D., Zhou, J., Liu, H., et al. Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage. Sci. Adv. 8(39), eabq2423 (2022).