A CXCL9-derived peptide
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CXCL9 (74-103) (human) (trifluoroacetate salt)

Item No. 38849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Chemokine (C-X-C motif) Ligand 9 (74-103)
  • MIG30
  • Monokine Induced by Interferon-γ (74-103)
Molecular Formula
C158H295N59O40 • XCF3COOH
Formula Weight
3661.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C158H295N59O40.C2HF3O2/c1-86(2)78-112(148(249)202-103(49-20-33-73-170)146(247)214-123(87(3)4)152(253)208-107(53-37-77-187-158(182)183)136(237)195-101(47-18-31-71-168)139(240)212-116(84-219)151(252)207-111(57-61-120(176)225)144(245)201-106(52-36-76-186-157(180)181)140(241)213-115(83-218)150(251)203-105(51-35-75-185-156(178)179)135(236)205-109(55-59-118(174)223)141(242)196-97(43-14-27-67-164)133(234)200-104(50-21-34-74-171)147(248)216-125(89(7)220)154(255)217-126(90(8)221)155(256)257)211-153(254)124(88(5)6)215-145(246)102(48-19-32-72-169)199-132(233)95(41-12-25-65-162)194-131(232)96(42-13-26-66-163)197-143(244)110(56-60-119(175)224)206-149(250)113(79-91-81-184-85-189-91)209-137(238)99(45-16-29-69-166)192-129(230)93(39-10-23-63-160)190-122(227)82-188-128(229)114(80-121(177)226)210-138(239)100(46-17-30-70-167)198-142(243)108(54-58-117(173)222)204-134(235)98(44-15-28-68-165)193-130(231)94(40-11-24-64-161)191-127(228)92(172)38-9-22-62-159;3-2(4,5)1(6)7/h81,85-90,92-116,123-126,218-221H,9-80,82-84,159-172H2,1-8H3,(H2,173,222)(H2,174,223)(H2,175,224)(H2,176,225)(H2,177,226)(H,184,189)(H,188,229)(H,190,227)(H,191,228)(H,192,230)(H,193,231)(H,194,232)(H,195,237)(H,196,242)(H,197,244)(H,198,243)(H,199,233)(H,200,234)(H,201,245)(H,202,249)(H,203,251)(H,204,235)(H,205,236)(H,206,250)(H,207,252)(H,208,253)(H,209,238)(H,210,239)(H,211,254)(H,212,240)(H,213,241)(H,214,247)(H,215,246)(H,216,248)(H,217,255)(H,256,257)(H4,178,179,185)(H4,180,181,186)(H4,182,183,187);(H,6,7)/t89-,90-,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,123+,124+,125+,126+;/m1./s1
InChi Key
FUXNRWJKZSPRHI-KZXWNIDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Chemokine (C-X-C motif) ligand 9 (CXCL9) (74-103) is a C-terminal fragment of mature CXCL9.1 It binds to the glycosaminoglycan heparin in a cell-free assay (Kd = 3.1 nM).2 CXCL9 (74-103) inhibits the binding of CXCL8 or CXCL11 to heparin, as well as chemokine (C-C motif) ligand 2 (CCL2) binding to heparan sulfate, in a concentration-dependent manner.1 Unlike full-length CXCL9, CXCL9 (74-103) does not increase intracellular calcium levels in CHO cells expressing human CXC receptor 3 (CXCR3). CXCL9 (74-103) reduces the cytopathogenic effect of respiratory syncytial virus (RSV) in HeLa cells, herpes simplex virus 1 (HSV-1) in human embryonic lung (HEL) cells, and dengue virus serotype 2 in HMEC-1 cells (EC50s = 23, 15, and 11 µM, respectively).2 It inhibits CXCL8 (1-77)- or monosodium urate-induced neutrophil extravasation to the tibiofemoral articulation in mouse models of acute inflammation or gout, respectively, when administered at a dose of 100 µg/animal.1 CXCL9 (74-103) increases survival and decreases liver neutrophil infiltration and necrosis in a mouse model of liver injury induced by acetaminophen (Item No. 10024).3 Intravenous administration of CXCL9 (74-103) (100 µl of a 1 mg/ml solution) decreases bronchoalveolar lavage fluid (BALF) neutrophil infiltration and IL-1β levels, but does not reduce lung bacterial burden, in a mouse model of K. pneumoniae-induced pneumonia.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vanheule, V., Janssens, R., Boff, D., et al. The positively charged COOH-terminal glycosaminoglycan-binding CXCL9(74-103) peptide inhibits CXCL8-induced neutrophil extravasation and monosodium urate crystal-induced gout in mice. The Journal of Biological Chemisty 290(35), 21292-21304 (2015).

    2. Vanheule, V., Vervaeke, P., Mortier, A., et al. Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus. Biochem. Pharmacol. 100, 73-85 (2016).

    3. Marques, P.E., Vandendriessche, S., de Oliveira, T.H.C., et al. Inhibition of drug-induced liver injury in mice using a positively charged peptide that binds DNA. Hepatol. Commun. 5(10), 1737-1754 (2021).

    4. Boff, D., Russo, R.C., Crijns, H., et al. The therapeutic treatment with the GAG-binding chemokine fragment CXCL9(74-103) attenuates neutrophilic inflammation and lung dysfunction during Klebsiella pneumoniae infection in mice. Int. J. Mol. Sci. 23(11), 6246 (2022).