A PDE5 inhibitor
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Homosildenafil

Item No. 38891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS Number
642928-07-2
Synonyms
  • Methylsidenafil
Molecular Formula
C23H32N6O4S
Formula Weight
488.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=S(C1=CC(C(NC2=C3N(C)N=C2CCC)=NC3=O)=C(OCC)C=C1)(N4CCN(CC4)CC)=O
InChi Code
InChI=1S/C23H32N6O4S/c1-5-8-18-20-21(27(4)26-18)23(30)25-22(24-20)17-15-16(9-10-19(17)33-7-3)34(31,32)29-13-11-28(6-2)12-14-29/h9-10,15H,5-8,11-14H2,1-4H3,(H,24,25,30)
InChi Key
MJEXYQIZUOHDGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $131

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    10 mg

    $248

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    Product Description

    Homosildenafil is an inhibitor of phosphodiesterase 5 (PDE5; IC50 = 8.9 nM).1 It has been found as an adulterant in dietary supplements for erectile dysfunction.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blount, M.A., Beasley, A., Zoraghi, R., et al. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation. Mol. Pharmacol. 66(1), 144-152 (2004).

    2. Blok-Tip, L., Zomer, B., Bakker, F., et al. Structure elucidation of sildenafil analogues in herbal products. Food Addit. Contam. 21(8), 737-748 (2004).

    3. Lee, E.S., Lee, J.H., Han, K.M., et al. Simultaneous determination of 38 phosphodiestrase-5 inhibitors in illicit erectile dysfunction products by liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal. 83, 171-178 (2013).