An unnatural amino acid
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AbK

Item No. 38895

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N6-[[2-(3-methyl-3H-diazirin-3-yl)ethoxy]carbonyl]-L-lysine
CAS Number
1253643-88-7
Synonyms
  • DiAzKs
  • H-L-Photo-lysine
Molecular Formula
C11H20N4O4
Formula Weight
272.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Aqueous acid: solubleWater: slightly soluble upon warming
SMILES
O=C(O)[C@@H](N)CCCCNC(OCCC1(N=N1)C)=O
InChi Code
InChI=1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1
InChi Key
LUCMNTLJAFTFDU-QMMMGPOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $200

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    10 mg

    $377

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    25 mg

    $732

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    Product Description

    AbK is an unnatural amino acid1 It has been incorporated into proteins via a modified aminoacyl-tRNA synthetase and used to cross-link proteins in bacteria or mammalian cells.1,2 It has been incorporated into the RNA-binding protein iron regulatory protein 1 (IRP1) and used in the study of RNA-protein interactions in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ai, H.-W., Shen, W., Sagi, A., et al. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid. Chembiochem 12(12), 1854-1857 (2011).

    2. Dziuba, D., Hoffmann, J.-E., Hentze, M.W., et al. A genetically encoded diazirine analogue for RNA-protein photo-crosslinking. Chembiochem 21(1-2), 88-93 (2020).