A PROTAC precursor
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VH 032 Linker 6

Item No. 38898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-3-methyl-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide
CAS Number
2098799-80-3
Molecular Formula
C31H42N4O7S
Formula Weight
614.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/ml
SMILES
O=C([C@@H](NC(COCCOCCOCC#C)=O)C(C)(C)C)N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O
InChi Code
InChI=1S/C31H42N4O7S/c1-6-11-40-12-13-41-14-15-42-19-26(37)34-28(31(3,4)5)30(39)35-18-24(36)16-25(35)29(38)32-17-22-7-9-23(10-8-22)27-21(2)33-20-43-27/h1,7-10,20,24-25,28,36H,11-19H2,2-5H3,(H,32,38)(H,34,37)/t24-,25+,28-/m1/s1
InChi Key
HHXQNDSXTCIWSG-CERRFVOPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

    $109

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    25 mg

    $259

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    Product Description

    VH 032 linker 6 is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal alkyne conjugated via a PEG linker to VHL ligand 1 (Item No. 21591), which binds to VHL E3 ligase.1 It has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, D., Zheng, G., Zhang, X., et al. Compositions targeting senescent cells and the uses thereof. US 2019/0054097 Al, (2019).