A cationic lipid
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1,2-Dipalmitoyl-3-trimethylammoniumpropane (chloride)

Item No. 38907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,N-trimethyl-2,3-bis[(1-oxohexadecyl)oxy]-1-propanaminium, monochloride
CAS Number
139984-36-4
Synonyms
  • DPTAP
  • 16:0 TAP
Molecular Formula
C38H76NO4 • Cl
Formula Weight
646.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly soluble
SMILES
O=C(OC(C[N+](C)(C)C)COC(CCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCCCC.[Cl-]
InChi Code
InChI=1S/C38H76NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-37(40)42-35-36(34-39(3,4)5)43-38(41)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h36H,6-35H2,1-5H3;1H/q+1;/p-1
InChi Key
KYARZEFZZOGPGS-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Product Description

    DPTAP is a cationic lipid that has been used as a transfection reagent in vitro and in vivo and in the formation of liposomes and microbubbles.1,2,3 Microbubbles containing DPTAP and encapsulating the microRNA (miRNA) miR-145 reduce atherosclerotic plaque area by 48.04% using ultrasound-targeted microbubble destruction (UTMD) in ApoE-/- mice in a model of atherosclerosis induced by a high-fat diet.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lemmon, J.C.M., McFarland, R.J., Rybicka, J.M., et al. In vitro and in vivo transfection of primary phagocytes via microbubble-mediated intraphagosomal sonoporation. J. Immunol. Methods 371(1-2), 152-158 (2011).

    2. Barnier Quer, C., Elsharkawy, A., Romeijn, S., et al. Cationic liposomes as adjuvants for influenza hemagglutinin: More than charge alone. Eur. J. Pharm. Biopharm. 81(2), 294-302 (2012).

    3.  Enhanced local delivery of microRNA-145a-5P into mouse aorta via ultrasound-targeted microbubble destruction inhibits atherosclerotic plaque formation. Mol. Pharm. 20(2), 1086-1095.