A microbial metabolite with antibiotic and anticancer activities
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Bactobolin A (hydrochloride)

Item No. 38912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-N-[(3S,4R,4aR,5R,6R)-3-(dichloromethyl)-3,4,4a,5,6,7-hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2-benzopyran-4-yl]-propanamide, monohydrochloride
CAS Number
73543-68-7
Synonyms
  • BN-183B
Molecular Formula
C14H20Cl2N2O6 • HCl
Formula Weight
419.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
[H][C@@]12[C@H]([C@@H](CC(O)=C1C(O[C@](C)(C(Cl)Cl)[C@@H]2NC([C@H](C)N)=O)=O)O)O.Cl
InChi Code
InChI=1S/C14H20Cl2N2O6.ClH/c1-4(17)11(22)18-10-8-7(5(19)3-6(20)9(8)21)12(23)24-14(10,2)13(15)16;/h4,6,8-10,13,19-21H,3,17H2,1-2H3,(H,18,22);1H/t4-,6+,8-,9-,10+,14-;/m0./s1
InChi Key
AKPKWIDQDYLTIW-IQGHTCFGSA-N
Origin
Bacterium/Pseudomonas sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Bactobolin A is a microbial metabolite originally isolated from Pseudomonas and has antibiotic and anticancer activities.1 It is active against S. aureus, S. epidermidis, S. faecalis, B. anthracis, B. subtilis, E. coli, S. typhi, and S. dysenteriae (MICs = 0.1-12.5 µg/ml). In vivo, bactobolin A (0.25-4 mg/kg) increases survival in an L1210 murine leukemia model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ezaki, N., Miyadoh, S., Hisamatsu, T., et al. BN-183B, a new antitumor antibiotic produced by Pseudomonas. Taxonomy, isolation, physico-chemical and biological properties. J. Antibiot. (Tokyo) 33(2), 213-220 (1980).