An ionizable cationic lipid
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RM 137-15

Item No. 38918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9Z,9'Z)-((3,3'-((2-(4-methylpiperazin-1-yl)ethyl)azanediyl)bis(propanoyl))bis(oxy))bis(octadec-9-ene-18,7-diyl) (4Z,4'Z,7Z,7'Z,10Z,10'Z,13Z,13'Z,16Z,16'Z,19Z,19'Z)-bis(docosa-4,7,10,13,16,19-hexaenoate)
CAS Number
3117189-62-2
Molecular Formula
C93H153N3O8
Formula Weight
1441.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 25 mg/ml
SMILES
O=C(OCCCCCCCC/C=C\CC(CCCCCC)OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)CCN(CCC(OCCCCCCCC/C=C\CC(CCCCCC)OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)=O)CCN1CCN(C)CC1
InChi Code
InChI=1S/C93H153N3O8/c1-6-10-14-18-20-22-24-26-28-30-32-34-36-38-40-46-52-58-66-74-92(99)103-88(70-62-16-12-8-3)72-64-56-50-44-42-48-54-60-68-86-101-90(97)76-78-95(84-85-96-82-80-94(5)81-83-96)79-77-91(98)102-87-69-61-55-49-43-45-51-57-65-73-89(71-63-17-13-9-4)104-93(100)75-67-59-53-47-41-39-37-35-33-31-29-27-25-23-21-19-15-11-7-2/h10-11,14-15,20-23,26-29,32-35,38-41,52-53,56-59,64-65,88-89H,6-9,12-13,16-19,24-25,30-31,36-37,42-51,54-55,60-63,66-87H2,1-5H3/b14-10-,15-11-,22-20-,23-21-,28-26-,29-27-,34-32-,35-33-,40-38-,41-39-,58-52-,59-53-,64-56-,65-57-
InChi Key
XDTKLSKXCYCJIA-VRMIVSQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $80

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    5 mg

    $377

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    10 mg

    $674

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    25 mg

    $1,089

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    Cayman Chemical
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    Product Description

    RM 137-15 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing RM 137-15 and encapsulating mRNA encoding a fluorescent reporter increase fluorescence in the livers of mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rhym, L.H., Manan, R.S., Koller, A., et al. Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery. Nat. Biomed. Eng. 7(7), 901-910 (2023).