A PROTAC that drives aptamer-defined protein degradation
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Dth

Item No. 38925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-4-((6-(4-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)hexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Molecular Formula
C30H29F2N5O6
Formula Weight
593.6
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
FC1=C(O)C(F)=CC(/C=C2N=C(C)N(CCCCCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)C\2=O)=C1
InChi Code
InChI=1S/C30H29F2N5O6/c1-16-34-22(15-17-13-19(31)26(39)20(32)14-17)29(42)36(16)12-5-3-2-4-11-33-21-8-6-7-18-25(21)30(43)37(28(18)41)23-9-10-24(38)35-27(23)40/h6-8,13-15,23,33,39H,2-5,9-12H2,1H3,(H,35,38,40)/b22-15-
InChi Key
PSAVYAATVZHVSR-JCMHNJIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $164

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    1 mg

    $312

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    5 mg

    $1,230

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    Product Description

    Dth is a proteolysis-targeting chimera (PROTAC) composed of the fluorescent probe for RNA DFHBI (Item No. 34555) and the immunomodulatory compound thalidomide (Item No. 14610).1 It binds to a genetically expressed RNA aptamer comprising Broccoli and a modifiable and selective protein targeting sequence and induces degradation of mCherry in HEK293T cells when used at a concentration of 20 µM. Dth (20 µM) induces degradation of the NF-κB subunit p50, as well as p50 and the E2F transcription factor subtype E2F1, in MCF-7 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Y., Fu, D., Yuan, Y., et al. A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function. Cell Rep. Phys. Sci. 3(10), 101064 (2022).