A PROTAC that drives ferritin degradation
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Ferritin PROTAC DeFer-2

Item No. 38931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,4R)-1-((S)-3,3-dimethyl-2-(4-oleamidobutanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Synonyms
  • Ferritin Proteolysis-targeting Chimera DeFer2
Molecular Formula
C44H69N5O5S
Formula Weight
780.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): Slightly
SMILES
CC1=C(C2=CC=C(CNC([C@@H](N3C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)C(C)(C)C)=O)C[C@H](C3)O)=O)C=C2)SC=N1
InChi Code
InChI=1S/C44H69N5O5S/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-38(51)45-28-21-23-39(52)48-41(44(3,4)5)43(54)49-31-36(50)29-37(49)42(53)46-30-34-24-26-35(27-25-34)40-33(2)47-32-55-40/h13-14,24-27,32,36-37,41,50H,6-12,15-23,28-31H2,1-5H3,(H,45,51)(H,46,53)(H,48,52)/b14-13-/t36-,37+,41-/m1/s1
InChi Key
FOJJJSRIPHLZFB-HJBYGEKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    5 mg

    $401

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    10 mg

    $758

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    Cayman Chemical
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    Product Description

    Ferritin PROTAC DeFer-2 is a proteolysis-targeting chimera (PROTAC) containing oleic acid (Item Nos. 90260 | 24659), which binds to ferritin dimers, conjugated to von Hippel-Lindau ligand (VHL ligand 1; Item No. 21591), which binds to VHL E3 ligase, via an alkyl linker.1 It induces ferritin degradation in B16/F10 murine melanoma cells when used at a concentration of 0.5 µM, an effect not induced by a negative control with an inverted VHL ligand 1 stereocenter, indicating that the E3 ligase activity of VHL ligand 1 is required for this effect. Ferritin PROTAC DeFer-2 (5 µM) increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells. Ferritin PROTAC De-Fer-2 (10 mg/kg) encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Y., Li, W., Kwon, S., et al. Small-molecule ferritin degrader as a pyroptosis inducer. J. Am. Chem. Soc. 145(17), 9815-9824 (2023).