A 15-LO-1 inhibitor
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ThioLox

Item No. 38946

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-butyl-5-phenyl-3-thiophenecarboxamide
CAS Number
1202193-89-2
Molecular Formula
C15H18N2OS
Formula Weight
274.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
232, 330 nm
SMILES
O=C(NCCCC)C1=C(N)SC(C2=CC=CC=C2)=C1
InChi Code
InChI=1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18)
InChi Key
QWWMJRJCSZMXHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $119

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    25 mg

    $279

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    50 mg

    $494

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    Product Description

    ThioLox is an inhibitor of 15-lipoxygenase 1 (15-LO-1; Ki = 3.3 µM).1 It also is an inhibitor of P. falciparum aspartate carbamoyltransferase (IC50 = 3.32 µM).2 ThioLox (50 µM) reduces LPS-induced expression of the mRNAs encoding TNF-α, inducible nitric oxide synthase (iNos), Il-1β, Il-6, Il-8, and Il-12b in mouse lung slices.1 It inhibits increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, induced by the excitatory neurotransmitter glutamate (L-glutamic acid; Item No. 30377) in mouse HT22 hippocampal cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eleftheriadis, N., Poelman, H., Leus, N.G.J., et al. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur. J. Med. Chem. 122, 786-801 (2016).

    2. Wang, C., Zhang, B., Krüger, A., et al. Discovery of small-molecule allosteric inhibitors of PfATC as antimalarials. J. Am. Chem. Soc. 144(41), 19070-19077 (2022).