A neuroprotective agent
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p-methyl-N-salicyloyl Tryptamine

Item No. 38958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N-[2-(1H-indol-3-yl)ethyl]-4-methyl-benzamide
CAS Number
1371564-45-2
Synonyms
  • LZWL02003
  • para-methyl-N-salicyloyl Tryptamine
Molecular Formula
C18H18N2O2
Formula Weight
294.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
SMILES
O=C(C1=CC=C(C)C=C1O)NCCC2=CNC3=CC=CC=C32
InChi Code
InChI=1S/C18H18N2O2/c1-12-6-7-15(17(21)10-12)18(22)19-9-8-13-11-20-16-5-3-2-4-14(13)16/h2-7,10-11,20-21H,8-9H2,1H3,(H,19,22)
InChi Key
IIXQVHOWQHXBKW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $96

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    25 mg

    $224

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    Product Description

    p-methyl-N-salicyloyl Tryptamine is a neuroprotective agent and derivative of N-salicyloyl tryptamine.1 It reduces LPS-induced nitric oxide (NO) production in C6 rat glioma cells and BV-2 mouse microglia (IC50s = 7.48 and 4.94 µM, respectively). It also reduces LPS-induced production of TNF-α and prostaglandin E2 (PGE2; Item No. 14010) and increases production of IL-10 in BV-2 microglia when used at a concentration of 40 µM. In vivo, p-methyl-N-salicyloyl tryptamine (25-100 mg/kg) decreases cortical and hippocampal amyloid-β (Aβ) plaque formation and neuronal pyroptosis, as well as improves spatial learning and memory, in a mouse model of Aβ-induced Alzheimer’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fan, X., Li, J., Deng, X., et al. Design, synthesis and bioactivity study of N-salicyloyl tryptamine derivatives as multifunctional agents for the treatment of neuroinflammation. Eur. J. Med. Chem. 193, 112217 (2020).

    2. Bai, Y., Liu, D., Zhang, H., et al. N-salicyloyl tryptamine derivatives as potential therapeutic agents for Alzheimer’s disease with neuroprotective effects. Bioorg. Chem. 115, 105255 (2021).