Negletein

Negletein is a flavonoid that has been found in S. oblonga and has diverse biological activities.^1,2,3 It inhibits biofilm formation by S. aureus, B. subtilis, P. aeruginosa, and E. coli when used at a concentration of 32 µg/ml.¹ Negletein induces cytotoxicity in SW460 and DLD-1 colorectal cancer cells (IC₅₀s = 29.41 and 30.93 µM, respectively) but not HT-29 colon cancer or HepG2 hepatocellular carcinoma cells (IC₅₀s = >40 µM for both).⁴ It decreases LPS-induced nitric oxide (NO) production and secreted TNF-α and IL-1β levels in J774A.1 macrophages when used at a concentration of 0.01 µM.² Negletein (10 µM), alone and in combination with nerve growth factor (NGF), increases neurite outgrowths, levels of growth-associated protein 43 (GAP43) and decreases serum deprivation-induced death in PC12 adrenal medulla cells.³

WARNING This product is not for human or veterinary use.

1. Rajendran, N., Subramaniam, S., Christena, L.R., et al. Antimicrobial flavonoids isolated from Indian medicinal plant Scutellaria oblonga inhibit biofilms formed by common food pathogens. Nat. Prod. Res. 30(17), 2002-2006 (2016).

2. Singh, B., Sidiq, T., Joshi, P., et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth. Nat. Prod. Res. 27(23), 2227-2230 (2013).

3. Phan, C.-W., Sabaratnam, V., Bovicelli, P., et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors 42(6), 591-599 (2016).

4. Wang, S.-H., Chen, C.-H., Lo, C.-Y., et al. Synthesis and biological evaluation of novel 7-O-lipophilic substituted baicalein derivatives as potential anticancer agents. Med. Chem. Comm. 6, 1864-1873 (2015).