An IRF3 activator and adjuvant
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KIN1148

Item No. 38980

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-benzo[1,2-d:3,4-d′]bisthiazol-2-yl-2-naphthalenecarboxamide
CAS Number
1428729-56-9
Molecular Formula
C19H11N3OS2
Formula Weight
361.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: Slightly soluble
λmax
217, 249, 310, 326 nm
SMILES
O=C(C1=CC2=C(C=CC=C2)C=C1)NC3=NC4=C(S3)C5=C(SC=N5)C=C4
InChi Code
InChI=1S/C19H11N3OS2/c23-18(13-6-5-11-3-1-2-4-12(11)9-13)22-19-21-14-7-8-15-16(17(14)25-19)20-10-24-15/h1-10H,(H,21,22,23)
InChi Key
YAISOECYKYATLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    5 mg

    $359

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    10 mg

    $590

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    25 mg

    $948

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    Cayman Chemical
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    Product Description

    KIN1148 is an IFN regulating factor 3 (IRF3) activator and adjuvant.1 It increases the mRNA expression of the genes encoding IFN-stimulated gene 54 (ISG54) and 2'-5'-oligoadenylate synthase-like (OASL) protein in PH5CH8 cells and increases chemokine (C-X-C motif) ligand 10 (CXCL10) production in phorbol 12-myristate 13-acetate-differentiated THP-1 monocytes when used at a concentration of 10 µM. Immunization with a vaccine in combination with KIN1148 as an adjuvant increases blood IgG, neutralizing, and hemagglutinin antibody titers, decreases particle-forming units (PFUs) in the lungs and lung-draining lymph nodes, and increases the survival percentage of mice infected with a lethal dose of influenza virus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Probst, P., Grigg, J.B., Wang, M., et al. A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response. Vaccine 35(15), 1964-1971 (2017).