A long-chain acylcarnitine and GlyT2 inhibitor
Related Products
Alternative(s)
26557Oleoyl-L-carnitine
Labeled Version(s)
26578Oleoyl-L-carnitine-d3 (chloride)
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Oleoyl-L-carnitine (chloride)

Item No. 39014

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-carboxy-N,N,N-trimethyl-2-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monochloride
CAS Number
31062-78-9
Synonyms
  • CAR 18:1
  • C18:1 Carnitine
  • L-Carnitine oleoyl ester
  • L-Octadecanoylcarnitine
Molecular Formula
C25H48NO4 • Cl
Formula Weight
462.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC(C[C@H](C[N+](C)(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-]
InChi Code
InChI=1S/C25H47NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4;/h12-13,23H,5-11,14-22H2,1-4H3;1H/b13-12-;/t23-;/m1./s1
InChi Key
JPDKUMDAMZLOJR-KFQPROOXSA-N
Side Chain Carbon Sum
18:1
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Oleoyl-L-carnitine is a long-chain acylcarnitine and an inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM).1,2 It is selective for GlyT2 over GlyT1 (IC50 = >10,000 nM). Plasma levels of oleoyl-L-carnitine are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kalim, S., Clish, C.B., Wenger, J., et al. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J. Am. Heart Assoc. 2(6), e000542 (2013).

    2. Carland, J.E., Mansfield, R.E., Ryan, R.M., et al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br. J. Pharmacol. 168(4), 891-902 (2013).