An AChE inhibitor
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MR2938

Item No. 39035

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dimethoxy-2-[4-(4-methyl-1-piperazinyl)]-4(3H)-quinazolinone
CAS Number
1044870-65-6
Molecular Formula
C21H24N4O3
Formula Weight
380.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): Slightly
SMILES
O=C1N=C(C2=CC=C(N3CCN(CC3)C)C=C2)NC4=C1C(OC)=CC(OC)=C4
InChi Code
InChI=1S/C21H24N4O3/c1-24-8-10-25(11-9-24)15-6-4-14(5-7-15)20-22-17-12-16(27-2)13-18(28-3)19(17)21(26)23-20/h4-7,12-13H,8-11H2,1-3H3,(H,22,23,26)
InChi Key
RVCUXKFESITCJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $208

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    10 mg

    $395

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    Cayman Chemical
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    Product Description

    MR2938 is an inhibitor of acetylcholinesterase (AChE; IC50 = 5.04 µM).1 It is selective for AChE over butyrylcholinesterase (BChE; IC50 = >20 µM). MR2938 inhibits nitric oxide (NO) production in RAW 264.7 cells (IC50 = 3.29 µM). It reverses LPS-induced increases in NF-κB and NOD-like receptor protein 3 (NLRP3) protein levels in BV-2 microglial cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lv, L., Maimaitiming, M., Huang, Y., et al. Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities. Eur. J. Med. Chem. 254, 115346 (2023).