An amine-functionalized hydrophilic polymer
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DSPE-Polysarcosine66

Item No. 39052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-((hydroxy(2-(2-(methyl((methylamino)methyl)amino)acetamido)ethoxy)phosphoryl)oxy)propane-1,2-diyl distearate
Synonyms
  • 1,2-Dioctadecanoyl-sn-glycero-3-Phosphoethanolamine-Polysarcosine66
  • 1,2-Distearoyl-sn-glycero-3-PE Polysarcosine66
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polysarcosine66
  • 1,2-DSPE-Polysarcosine66
  • 18:0/18:0-PE-Polysarcosine66
  • DSPE-pSar66
  • PE(18:0/18:0)-Polysarcosine66
Molecular Formula
(C3H5NO)nC43H87N2O8P
Formula Weight
862.2
Purity
≥95%
Formulation (Request formulation change)
A solution in methanol
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@@](COP(O)(OCCNC(CN(C)CNC)=O)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)=O
InChi Code
InChI=1S/C46H92N3O9P/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-45(51)55-40-43(41-57-59(53,54)56-38-37-48-44(50)39-49(4)42-47-3)58-46(52)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h43,47H,5-42H2,1-4H3,(H,48,50)(H,53,54)/t43-/m1/s1
InChi Key
IEQBKEBGSVOKGN-VZUYHUTRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $109

    Add

    25 mg

    $242

    Add

    50 mg

    $424

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    DSPE-polysarcosine66 is an amine-functionalized hydrophilic polymer. It is a polysarcosine-labeled form of 1,2-distearoyl-rac-glycero-3-phosphoethanolamine (DSPE). Polysarcosines have been used as alternatives to PEGylation in lipid nanoparticles (LNPs) and to reduce the immunogenicity of administered proteins in vivo.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nogueira, S.S., Schlegel, A., Maxeiner, K., et al. Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery. ACS Appl. Nano Mater. 3(11), 10634-10645 (2020).

    2. Hu, Y., Hou, Y., Wang, H., et al. Polysarcosine as an alternative to PEG for therapeutic protein conjugation. Bioconjug. Chem. 29(7), 2232-2238 (2018).