An isoindolinone with diverse biological activities
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Hericerin

Item No. 39057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,3-dihydro-4-hydroxy-6-methoxy-2-(2-phenylethyl)-1H-isoindol-1-one
CAS Number
140381-53-9
Synonyms
  • Isohericerin
Molecular Formula
C27H33NO3
Formula Weight
419.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
C/C(C)=C/CC/C(C)=C/CC1=C(OC)C=C(C(N(CCC2=CC=CC=C2)C3)=O)C3=C1O
InChi Code
InChI=1S/C27H33NO3/c1-19(2)9-8-10-20(3)13-14-22-25(31-4)17-23-24(26(22)29)18-28(27(23)30)16-15-21-11-6-5-7-12-21/h5-7,9,11-13,17,29H,8,10,14-16,18H2,1-4H3/b20-13+
InChi Key
AYUFSIRZXDWSDR-DEDYPNTBSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Cayman Chemical
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    Product Description

    Hericerin is a polyketide synthase-derived isoindolinone that has been found in H. erinaceus and has diverse biological activities.1,2,3 It inhibits α-glucosidase (IC50 = 5.3 µM) and is cytotoxic to A549 lung and HeLa cervical cancer cells (IC50s = 49 and 40.5 µM, respectively).2 Hericerin induces neurite outgrowth in Neuro2a neuroblastoma cells and increases nerve growth factor (NGF) production in C6 glioma cells when used at concentrations of 25 and 50 µM, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Zeng, X., Yang, Y.L., et al. Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus. Sci. Rep. 7(1), 10151 (2017).

    2. Wang, K., Bao, L., Qi, Q., et al. Erinacerins C-L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J. Nat. Prod. 78(1), 146-154 (2015).

    3. Ryu, S.H., Hong, S.M., Khan, Z., et al. Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus. Bioorg. Med. Chem. Lett. 31, 127714 (2021).