An amine-terminated PAMAM dendrimer
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PAMAM Dendrimer G2.0 Amine (water solution)

Item No. 39072

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-propenoic acid, polymer with 1,2-ethanediamine, methyl ester
CAS Number
26937-01-9
Synonyms
  • PAMAM G2.0
  • Polyamidoamine Dendrimer G2.0
Molecular Formula
[NH2(CH2)2NH2]:(G=2);dendri PAMAM(NH2)16
Formula Weight
3256.2
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $98

    Add

    1 g

    $186

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    PAMAM dendrimer G2.0 amine (PAMAM G2.0) is a polyamidoamine (PAMAM) dendrimer with amine termini.1 It is approximately 29 Å in diameter and has 16 surface groups. PAMAM G2.0 (15 mg/ml) in combination with erythromycin (Item No. 16486) enhances the solubility and antibacterial activity of erythromycin against S. aureus.2 It increases the cell growth rate of HEK293T and HeLa cells when used at concentrations ranging from 100 to 500 nM but is cytotoxic to the same cells when used at concentrations greater than or equal to 700 nM.3 In vivo, PAMAM G2.0 when administered in combination with fluorescein isothiocyanate-labeled dextran enhances its nasal absorption in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

    2. Winnicka, K., Wroblewska, M., Wieczorek, P., et al. The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility. Molecules 18(7), 8607-8617 (2013).

    3. Parimi, S., Barnes, T.J., Callen, D.F., et al. Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers. Biomacromolecules 11(2), 382-389 (2010).

    4. Dong, Z., Katsumi, H., Sakane, T., et al. Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats. Int. J. Pharm. 393(1-2), 244-252 (2010).