PAMAM Dendrimer G3.0 Amine (water solution)

PAMAM dendrimer G3.0 amine (PAMAM G3.0) is a polyamidoamine (PAMAM) dendrimer with amine termini that has been used as a drug delivery system in vivo.^1,2 It is approximately 36 Å in diameter and has 32 surface groups.¹ It is cytotoxic to DU145 cells (IC₅₀ = ^~13.42 µM) and toxic to zebrafish embryos, inducing mortality 72 hours post-fertilization when used at a concentration of 0.2 µM.³ Liposomes coated with PAMAM G3.0 and encapsulating the isoquinoline alkaloid berberine (Item No. 10006427) and the anthraquinone chrysophanol (Item No. 19870) reduce hydrogen peroxide-induced production of reactive oxygen species (ROS) in ARPE-19 retinal epithelial cells and protect against retinal damage in a rat model of photooxidation-induced age-related macular degeneration (AMD).²

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1. Heiden, T.C., Dengler, E., Kao, W.J., et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol. Appl. Pharmacol. 225(1), 70-79 (2007).

2. Lai, S., Wei, Y., Wu, Q., et al. Liposomes for effective drug delivery to the ocular posterior chamber. J. Nanobiotechnology 17(1), 64 (2019).

3. Bodewein, L., Schmelter, F., Di Fiore, S., et al. Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicol. Appl. Pharmacol. 305, 83-92 (2016).