An inhibitor of microtubule polymerization
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S-72

Item No. 39083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-3-[[(4-methylphenyl)sulfonyl]amino]-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-benzamide
CAS Number
2446799-14-8
Molecular Formula
C20H22N4O3S
Formula Weight
398.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
SMILES
O=[S](NC1=CC(C(NCC(C=N2)=CN2C)=O)=CC=C1C)(C(C=C3)=CC=C3C)=O
InChi Code
InChI=1S/C20H22N4O3S/c1-14-4-8-18(9-5-14)28(26,27)23-19-10-17(7-6-15(19)2)20(25)21-11-16-12-22-24(3)13-16/h4-10,12-13,23H,11H2,1-3H3,(H,21,25)
InChi Key
GDFZUYYZZBJRBP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $127

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    25 mg

    $300

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    50 mg

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    Cayman Chemical
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    Product Description

    S-72 is an inhibitor of microtubule polymerization.1 It inhibits microtubule polymerization in a cell-free assay when used at concentrations 1, 3, and 10 µM. S-72 reduces viability in MCF-7 and paclitaxel-resistant MCF-7/T breast cancer cells (IC50s = 15.64 and 26.32 nM, respectively). It inhibits migration and invasion, as well as the percentage of wound closure in a scratch assay, in MCF-7 and MCF-7/T cells when used at a concentration of 50 nM. S-72 (100 nM) induces cell cycle arrest at the G2/M phase in MCF-7/T cells, as well as induces apoptosis in those same cells. It also inhibits stimulator of interferon genes (STING) activation in MCF-7/T cells when used at a concentration of 100 nM. S-72 (15 mg/kg per day) inhibits tumor growth in MCF-7/T and MX-1/T mouse xenograft models of paclitaxel-resistant breast cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, Z., Lin, S., Du, T., et al. S-72, a novel orally available tubulin inhibitor, overcomes paclitaxel resistance via inactivation of the STING pathway in breast cancer. Pharmaceuticals (Basel) 16(5), 749 (2023).