A hydroxyl-terminated PAMAM dendrimer
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PAMAM Dendrimer G2.0 Amidoethanol (water solution)

Item No. 39111

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM G2.0 Amidoethanol
  • Polyamidoamine Dendrimer G2.0 Amidoethanol
Molecular Formula
[NH2(CH2)2NH2]:(G=2);dendri PAMAM(NHCH2CH2OH)16
Formula Weight
3271.9
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $98

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    1 g

    $186

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    Product Description

    PAMAM dendrimer G2.0 amidoethanol (PAMAM G2.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vitro.1,2 It is approximately 29.4 Å in diameter in water and has 16 surface groups.3 PAMAM G2.0 amidoethanol is an antagonist of the pore-forming channel binary anthrax toxin protective antigen 63 (PA63) in lipid bilayers (IC50 = 142 nM).4 It inhibits the proliferation of MCF-7 and MDA-MB-231 breast cancer cells when used at a concentration of 100 µM.5 PAMAM G2.0 amidoethanol enhances the water solubility of the antibiotic erythromycin (Item No. 16486) and increases the antifungal activity of clotrimazole (Item No. 15278) against Candida.1,2 Fragmentation of PAMAM G2.0 amidoethanol with hydrogen peroxide produces a fluorescent unsaturated hydroxylamine, which selectively detects hypochlorite over several other reactive oxygen species (ROS) and has been used to detect intracellular hypochlorite levels in RAW 246.7 macrophages.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Winnicka, K., Wroblewska, M., Wieczorek, P., et al. The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility. Molecules 18(7), 8607-8617 (2013).

    2. Winnicka, K., Sosnowska, K., Wieczorek, P., et al. Poly(amidoamine) dendrimers increase antifungal activity of clotrimazole. Biol. Pharm. Bull. 34(7), 1129-1133 (2011).

    3. Gonzalo, S., Rodea-Palomares, I., Leganés, F., et al. First evidences of PAMAM dendrimer internalization in microorganisms of environmental relevance: A linkage with toxicity and oxidative stress. Nanotoxicology 9(6), 706-718 (2015).

    4. Yamini, G., Kalu, N., and Nestorovich, E.M. Impact of dendrimer terminal group chemistry on blockage of the anthrax toxin channel: A single molecule study. Toxins (Basel) 8(11), 337 (2016).

    5. Winnicka, K., Bielawski, K., Rusak, M., et al. The effect of generation 2 and 3 poly(amidoamine) dendrimers on viability of human breast cancer cells. J. Health Sci. 55(2), 169-177 (2021).

    6. Wu, T.-H., Liu, C.-P., Chien, C.-T., et al. Fluorescent hydroxylamine derived from the fragmentation of PAMAM dendrimers for intracellular hypochlorite recognition. Chemistry 19(35), 11672-11675 (2013).